Pancreatic cancer is rarely diagnosed early on, when it is most treatable. This is due to the fact that it usually does not cause symptoms until it has spread to other organs. Pancreatic cancer starts in the tissues of your pancreas, an organ situated behind the lower part of your stomach in your abdomen. Your pancreas produces hormones that help digestion and releases enzymes that aid digestion. The pancreas may be affected by a number of tumours, both cancerous and noncancerous. The most common form of pancreas cancer starts in the cells that line the ducts that transport digestive enzymes from the pancreas (pancreatic ductal adenocarcinoma). A constant supply of nutrients is needed by all cancer cells. Some cancers accomplish this by forming their own vascular networks to draw nutrients from the blood supply of the host. Other cancers, such as pancreatic ductal adenocarcinoma, are surrounded by a thick layer of connective tissue and extracellular molecules (the so-called tumour stroma), which acts not only as a dividing line between malignant cells and normal host tissues, but also as a barrier to cancer cells receiving adequate resources, such as blood supply. Autophagy is increased in pancreatic cancer, so inhibiting self-eating may be used to starve tumours, according to previous research. Despite this, some clinical trials incorporating autophagic protein degradation inhibitors with standard chemotherapy found little additional therapeutic benefit over chemotherapy alone. Treatment choices for pancreatic cancer are determined by the cancer's stage. Surgery, chemotherapy, radiation therapy, or a combination of these can be used. Cellular adaptation refers to a cell's ability to respond to a variety of stimuli as well as adverse environmental changes. Hypertrophy (increase in cell number), hyperplasia (increase in cell number), atrophy (reduction in size and cell number), metaplasia (transformation from one type of epithelium to another), and dysplasia are examples of these adaptations (disordered growth of cells). Those who are interested to publish their article in our journal, they can submit it either send it as an email attachment to this below given mail id or submit it online through given link: https://www.longdom.org/submissions/medical-surgical-pathology.html

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Journal of Medical and Surgical Pathology

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ISSN: 2472-4971 | NLM ID: 101245791