Organic Chemical Synthesis

Organic chemistry is the study of the synthesis, structure, reactivity and properties of the diverse group of chemical compounds primarily constructed of carbon. All life on earth is carbon-based, thus organic chemistry is also the basis of biochemistry. The ability to form compounds containing long chains of carbon atoms is the basis of polymer chemistry.

Synthetic organic chemists have the power to replicate some of the most intriguing molecules of living nature in the laboratory and apply their developed synthetic strategies and technologies to construct variations of them. Such molecules facilitate biology and medicine, as they often find uses as biological tools and drug candidates for clinical development. In addition, by employing sophisticated catalytic reactions and appropriately designed synthetic processes, they can synthesize not only the molecules of nature and their analogues, but also myriad other organic molecules for potential applications in many areas of science, technology and everyday life. After a short historical introduction, this article focuses on recent advances in the field of organic synthesis with demonstrative examples of total synthesis of complex bioactive molecules, natural or designed, from the author’s laboratories, and their impact on chemistry, biology and medicine.

The chemistry of natural products was born in the eighteenth century, primarily from the work of the apothecaries, the pharmacists of the time, among whom Swedish Carl Wilhelm Scheele was the most prominent. He, besides being credited with the identification of oxygen, discovered several naturally occurring organic acids, including citric, gallic, malic, lactic, oxalic and uric acids. Scheele also developed important practical laboratory techniques such as distillation and crystallization.

The development of experimental methods for practical chemistry and the discoveries of naturally occurring substances such as urea, quinine, morphine and strychnine in the late eighteenth and early nineteenth centuries laid the foundations and provided the impetus for the emergence of organic synthesis

The impact of organic synthesis on science and technology does not stop with biology and medicine. It encompasses many other scientific and technological endeavours and facilitates their improvement, scope and reach. Among the most prominent fields that benefited enormously from applications of organic synthesis are those of molecular recognition and supramolecular chemistry, materials science and nanotechnology and chemical biology. Indeed, the universe of compounds synthesized by organic synthesis, natural and designed, is very large and could be almost infinite.

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With kind regards,
Nancy ella
Editorial Manager
Journal of Pharmaceutical Care & Health Systems