Immunotherapy is a Treatment to stimulate or restore the ability of the immune system to fight infection and disease. Immunotherapy is thus any form of treatment that uses the body's natural abilities that constitute the immune system to fight infection and disease or to protect the body from some of the side effects of treatment.

For nearly five decades, doctors have used various forms of immunotherapy to treat certain cancers. These treatments stimulate the patient’s own immune system to attack a disease, much like it would a virus or another foreign invader. Promising data have emerged to indicate its effectiveness against many cancers, including lung, kidney, melanoma, and some colon cancers.

Cancer cells can sometimes find ways to trick the immune system into thinking they are normal cells and should not be attacked. This allows them to grow and spread. One way this happens is through proteins called checkpoint proteins.

PD-L1 and PD-1 are types of checkpoint proteins. PD-LI is found on normal tissue surface and healthy cells, while PD-1 is often found on a type of white blood cells called T-cells. Some cancers disguise themselves by making their own PD-L1. When this happens, it binds to PD-1 on T-cells. These cells are then not spotted by the checkpoints which means the immune system does not destroy them. Undetected, the cancer cells can continue to grow without being slowed down or stopped. Immunotherapy treatments reactivates the immune system, helping it to recognise and attack the abnormal cancer cells. Some checkpoint inhibitors work by binding or sticking to the PD-1 on T-cells or PD-L1 on tumour cells.

 Immunotherapies stop PD-1 from binding to the PD-L1 on cancer cells. When this happens, the cancer cells can no longer trick the immune system.

Our journal is a scholarly journal maintains high standards of scientific excellence and its editorial board ensures a rapid peer review process with the help of the Editorial Manager System. The scope and discipline of the journal of  Immunological Disorders and Immunotherapy (ISSN: 2593-8509) is very broad which includes immune disorders caused by genetic variation related to monogenic as well as polygenic disorders, due to immune system over expressive or deformities, wide range of congenital or acquired disorders.  With the rapid advances in medicinal research, there is more need of advanced and durable study in Immunological Disorders and Immunotherapy field. The Journal of Immunological Disorders and Immunotherapy provides the platform to publish these new ideas. The journal serves to distribute the latest information and new idea in all related fields for effective and rapid communication among the research scholars, students, doctors.

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