Coronavirus disease 2019 (COVID-19) is a form of viral pneumonia caused by the coronavirus 2 that causes serious acute respiratory syndrome (SARS-CoV-2). After the extreme acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) in the twenty-first century, the emergence of SARS-CoV-2 was the third introduction of a highly pathogenic coronavirus into the human population. COVID-19 is not the first coronavirus-related acute respiratory disease outbreak. Coronaviruses have caused three epidemic diseases in the last two decades: COVID-19, extreme acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS). Coronaviruses are enveloped viruses with a 26–32 kb single-stranded RNA genome in the positive sense. Human coronaviruses (HCoVs) have been found in the coronavirus (HCoV-229E and NL63) and coronavirus (MERS-CoV, SARS-CoV, HCoV-OC43 and HCoV-HKU1) genera, with human coronaviruses (HCoVs) detected in the coronavirus (MERS-CoV, SARS-CoV, HCoV-OC43 and HCoV-HKU1) genera. Researchers in the United States have developed a novel protein that prevents mice infected with extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that triggers coronavirus disease – from developing lethal disease (COVID-19). During the early stages of infection, the team created a soluble, short, and dimeric version of the native host cell receptor, which is bound by a surface structure on SARS-CoV-2 called spike. In human kidney organoids, the team discovered that ACE2 1–618-ABD could neutralise SARS-CoV-2 infectivity. However, since the protein build is a monomer, the researchers hypothesised that viral spike trimers will be better suited to binding dimeric ACE2. Those who are interested to publish their article in our journal, they can submit it either send it as an email attachment to this below given mail id or submit it online through given link: https://www.longdom.org/submissions/medical-surgical-pathology.html

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ISSN: 2472-4971 | NLM ID: 101245791